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Featured Resources
3:03
Orthogonal Comparison of Analytical Methods by Intact Reconstruction

By using bottom-up data to build a theoretical reconstruction of the intact data and then juxtaposing it with the experimental intact data, differences and similarities between the two orthogonal methods can quickly be qualitatively determined.

24:47
Native MS and Cell Line Development

With increasing complexity and volume of biotherapeutics, Janssen describe how they are implementing Byosphere to bring clarity to manage their workflows and deliver concise information when and where its needed.
54:45
EPO: Separation and Analysis

EPO has also been historically very difficult to characterize by traditional approaches. Looking for a faster, simpler way of separating and analyzing?
2:38
Rapid Detection of Cross-Linked Dipeptides

The new Byos workflow resulted in the detection a photo-induced cross-linked dipeptide with unknown linker chemistry, which was subsequently identified as a cross-linked dipeptide with a novel Cysteine-Tryptophan linkage.

18:56
EU UGM 2022 – LC-MS and LC-MS/MS Analyses of Adeno-Associated Viruses Anc80

Jerome Jonveaux describes peptide and intact workflows developed for quantification of PTMs and comparison of AAV samples
5:04
Streamlining the Characterization of Disulfide Bond Shuffling and Protein Degradation in IgG1 Biopharmaceuticals Under Native and Stressed Conditions

By performing a semi-automated mass spectrometry method for characterizing disulfide bonds, as well as the SEC and SDS-PAGE methods, the authors were able to more seamlessly identify how bevacizumab and rituximab differ in their disulfide bond profile and degradation propensity.

38:49
EU UGM 2023: Bispecific Antibody Formats – Challenges in Peptide Mapping and how a Multi Enzyme Approach improves the Analysis of Sequence Variants

A new experimental set up utilizing a multi enzyme approach and the best approaches for quantification
46:12
Spotting the Outliers and New Peaks in MAM Runs Automatically

Unified data processing makes it easier to compare data within Dashboards and get the most out of your MAM results with no extra effort or pain
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