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Featured Resources
41.26
Unraveling the Twin Tales of Biosimilar and Innovator Glycans

N-glycans are omnipresent in the Fc region of monoclonal antibody products. Modifications to a glycan profile can impact a protein’s stability/folding, binding affinities, effector functions, clearance rates, and/or immunogenicity.
56:32
An Implementation of Vendor-Neutral Multi-Attribute Method (MAM)

Ben Niu speaks to setting up automatable workflows from sample preparation all the way through to data analysis and capable of handling a large number of samples.
29:34
Biosimilar Characterization

Seamlessly move between non-GxP and GxP to satisfy regulatory requirements with Byosphere. Regardless of the mass spec platform scientists can create workflows that allow comparisons with speed and with confidence
38:20
EAD: Making characterization of complex biotherapeutics routine

A new fragmentation technique with Sciex's ZenoTOF 7600 with a deep dive into the characterization of PTMs, S-S bond mapping and more with Byos
20:15
Automated Feedback Control of Protein Characteristics in a Perfusion Bioprocess

“Open-loop control” is standard control strategy for biomanufacturing – Critical Quality Attributes (CQAs) are maintained within set ranges by controlling Critical Process Parameters (CPPs). Mass spectrometry is an ideal tool for PAT.

24:47
Native MS and Cell Line Development

With increasing complexity and volume of biotherapeutics, Janssen describe how they are implementing Byosphere to bring clarity to manage their workflows and deliver concise information when and where its needed.
23:18
EU UGM 2023: Protein Metrics’ MAM application as a robust standard for PTM detection in large scale forced degradation studies

Creating robust standards and high throughput method development for large scale forced degradation studies and PTM reporting
27:29
Resolving Antibody Aggregation During Discovery & Development

Methods for analyzing footprinting data in the context of aggregation to arrive at actionable insights
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