What's New in Byos and Byosphere 6.0

Version 6.0 was released on April 22, 2026.

Version 6.0 introduces interactive theoretical digestion, the Multi-Protein Quantitation–DIA workflow for Byosphere (now with glycopeptide analysis and PEP scoring), and pI traces in Byosphere web analysis—plus folder-level signatures for autoprocessing, new trace-comparison tools, and sample metadata in Byosphere Dashboards.

📝 Byos v6.0 top new features

• Interactive theoretical digestion for searching in-silico peptides
• Multi-Protein Quan-DIA workflow now includes glycopeptide analyses
• Multi-Protein Quan-DIA workflow now reports posterior error probability (PEP) scores
• Enhanced charge state overlays in XIC plots for peptide workflows
• Additional fields for intact, oligo, progressive deconvolution and chromatography reports
• Ability to add stacked trace plots to reports
• New trace peak apex intensity and FWHM fields in Trace Peaks table in Intact and Oligo workflows

📝 Byosphere v6.0 top new features

• Multi-Protein Quan-DIA workflow is now available for Byosphere
• Autoprocessing support: Signature enabled at folder level
• Favorite Documents feature within Byosphere
• Favorite Dashboards shown on Dashboards Homepage
• Dashboards that handle Metadata in Deep Query 
• Users can now subscribe to background alerts in Dashboards
• New Comparison features for Trace analysis in web analysis
• pI traces now enabled in Byosphere web analysis
• Trace annotation improvements in Byosphere web analysis
• Ability to show, or hide all available fields in Byosphere web analysis tables
• Heatmap improvements available for streamlined inspection