What's New in Byos and Byosphere 5.9

Version 5.9 was released on April 25, 2025.

Version 5.9 introduces smart XIC alignment, expanded glycan and crosslinking annotations, and faster protein quantitation tools—plus major dashboard upgrades in Byosphere.

📝 Byos v5.9 Features

• Additional Multi-Protein Quantitation options for homologous proteins
• New Match Between Runs XIC alignment functionality
• Updated Multi-Protein Quantitation support for custom FDR targets
• Accelerated performance of Multi-Protein Identification project review
• New Preview workflow for low-complexity sample analysis
• Expanded Preview support for additional mass spec file formats
• Now universal use of faster XIC integration
• Increased oligo fragment annotation capabilities
• Additional custom N-Glycan motifs now enabled
• Enhanced identification of released glycans
• Protein Data Bank (PDB) 3D structures enabled for reporting
• Additional annotation of disulfide neutral loss ions
• Additional annotations for DSBU crosslinking fragments

📝 Byosphere v5.9 Top Features

• New Interactive Visualization Builder for Dashboards
• Enabled the ability to add Linear Regression, R2 and Pearson Correlation to Line charts
• Enabled the export of Dashboard visualization data into CSV outputs
• Enhanced numerical display settings for visualizations in Dashboards and for Tables in Web Analysis reports
• Updated Multi-protein quantitation-based HCP Dashboard template to include new visualizations with PPM quantitation
• Expanded Chromatogram datasource to allow querying specific released glycan data fields
• Enhanced Dashboard editing allows temporary reservation of edits 
• Extraction and saving of metadata information from MS files for further use within Byosphere
• Enhanced Trace plot annotations for Web analysis projects
• New Sample association feature to assign sequence combination to specific samples