Automated high-throughput screening of complex biologics

Automated, High-Throughput Screening of Complex Biologics

Traffic light validation brings clarity to high-throughput biologics screening

This automated system deconvolves intact-mass spectra, labels desired and undesired chain combinations, and presents results in an intuitive microtiter plate format—accelerating review of multispecific antibody characterization data.

• Intuitive Traffic Light Validation: User-defined business rules assign each sample to Pass, Fail, or Review categories, color-coded for instant interpretation. Non-experts can rapidly assess results without deep mass spectrometry expertise.
• Microtiter Plate Visualization: Results display in a 96-well plate format that mirrors laboratory operations, allowing users to quickly identify edge effects, spot trends, and navigate directly to underlying spectra.
• Automated Chain Combination Matching: The software identifies correctly formed hetero-IgG molecules alongside mis-formed and shuffled combinations by mass, supporting molecule design and expression/purification optimization.
• Browser-Based Review and Sharing: Byosphere's web analysis enables results to be shared within a closed, GxP-compliant system—providing global teams with rapid access to validated data without local software installation.
• Scalable for Growing Pipelines: With over 1,200 multispecific antibodies now in clinical trials, automated visualization and validation tools are essential to manage the data volumes that overwhelm manual review.