Streamlining CHO HCP Analysis with Byos Multi-Protein Quantitation
Discover how Byos enables sensitive, label-free HCP quantitation across CHO downstream steps—fast, scalable, and reproducible.
About This Webinar
Leveraging Byos Multi-Protein Quantitation workflow for high-throughput HCP monitoring in downstream processing for CHO-derived recombinant proteins
Join Somar Khalil, Principal Scientist at GSK Vaccines, for a follow-up session diving into the latest advances in high-throughput HCP monitoring using the Byos Multi-Protein Quantitation w
orkflow. Building on his earlier benchmarking study, this webinar highlights how the new workflow enables sensitive, multiplexed HCP analysis across downstream process steps for CHO-derived recombinant proteins. Learn how this streamlined, label-free approach supports decision-making with greater speed, depth, and consistency.
Learning Points:
- How the Multi-Protein Quantitation workflow in Byos enables scalable, label-free HCP tracking across multiple process steps
- Strategies for maximizing throughput and reproducibility in CHO-derived protein monitoring
- Interpreting quantitative HCP data to support process optimization and product quality
From The Webinar
On workflow advantages: "One of the practical advantages of the MPQ workflow, in my opinion, is how it improves quantification fidelity through better use of the match between runs... MPQ also allows filtering for peptides consistently... this really strengthens comparative analysis by focusing only on shared peptides... We can reduce false positives and probably potentially boost confidence in the data, both at the identification and the quantification levels." 36:40
On process tracking: "Using the multiprotein quantification workflow allowed us to track HCP clearance at high resolution, which supports both process understanding and comparability studies." 21:37
On mechanistic insights: "using MPQ workflow help us not only to be able to quantify the total host cell proteins, but also to be able to dissect mechanistic trends." 23:40
On overall performance: "MPQ successfully tracked SCP clearance across the different downstream verification steps with a clear reduction in complexity." 24:24