Cross-Linking MS for Rapid TCR Binding Mode Analysis

Webinar Abstract

Understanding how TCR-based therapeutics engage peptide-HLA complexes is critical—but traditional methods like crystallography are time-consuming and complex. In this webinar, we'll showcase a new cross-linking strategy combined with LC-MS/MS that dramatically accelerates structural insight into TCR binding modes. See how the Byosphere platform helps visualize results across protease and cross-linker combinations, enabling faster, more confident decision-making for therapeutic development. Whether you're mapping intra- or inter-protein interactions, this approach simplifies complexity and saves lab time.

Key Takeaways

Learn a faster alternative to crystallography - Discover how chemical cross-linkers and LC-MS/MS can quickly determine TCR orientation on peptide-HLA complexes.

See how to scale and streamline analysis in Byosphere - Explore how to combine multiple enzymes or cross-linkers in a single workflow, with intuitive visual reporting and comparison.

Gain insights to support structure-informed therapeutic design - Understand how cross-linking data feeds into structural models, reducing time-to-insight and enabling confident decision-making.

Our Speaker

Thomas Powell is a Senior Scientist in the Analytical Development group at Immunocore with over seven years of experience in the pharmaceutical industry. He holds a PhD from the University of Birmingham and specializes in mass spectrometry, with extensive expertise in identifying novel post-translational modifications relevant to biopharmaceuticals. More recently, he has focused on developing innovative mass spectrometry methods and integrating them into discovery pipelines in novel and impactful ways.