Automating Peptide Mapping: From Bench to Batch in Half the Time
How Genentech combined liquid handling automation with Byos software to save 2-3 days per week across disulfide, PTM, and glycation workflows
About This Webinar
Peptide mapping is indispensable for biotherapeutic characterization, but manual sample preparation and data analysis can consume days of analyst time each week. In this webinar, researchers from Genentech's Protein Analytical Chemistry group share how they automated three core peptide mapping workflows — disulfide mapping, reduced Lys-C PTM characterization, and Asp-N glycation analysis — using the TECAN Fluent 1080 liquid handling platform and Byos software from Protein Metrics. The result: a validated 30% improvement in throughput, freeing 2-3 days per week while maintaining analytical quality comparable to manual methods.
Key Takeaways
Automation without compromise — See head-to-head chromatographic and quantitative comparisons between manual and automated preparations across all three workflows, with RSD <15% for PTM quantification
One-click data analysis — Learn how preset Byos workflows transform complex disulfide, deamidation, and glycation analysis into a streamlined drag-and-drop process with compliance-ready reporting
Real-world time savings — Understand exactly where the 2-3 days per week are recovered: 7-9 hours from sample prep automation plus 1-2 days from standardized data analysis and reporting
Translatable methods — Walk away with a practical framework for automating your own peptide mapping workflows, including design considerations for buffer exchange steps and multi-enzyme digestion protocols
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