Protein Metrics

Protein Metrics Workflows

Protein Metrics’ workflow solutions will give you confidence in the results you report.  With a clear focus on protein characterization, we analyze your chromatography, capillary electrophoresis, and mass spectrometry data on our vendor neutral platform so that you can focus on your research.

For both junior analysts and 30-year mass spec savants our software simplifies and accelerates data analysis through a common, intuitive interface.   Supporting workflows across protein R&D, our software streamlines the most exacting procedures, such as assembling and reporting all relevant data in a single, analyst-relevant view, thereby eliminating bench-to-bench and lab-to-lab variability.

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Research labs in biomarker and therapeutic discovery rely on sensitive, accurate protein and peptide identification for many applications.

Protein Metrics’ Software Suite offers unparalleled quality of results in the identification of proteins and modified peptides in complex samples.  Our workflows dramatically reduce analysis time, whether studying novel glycoproteins, quantifying and reporting host cell proteins (HCPs), or sequencing an unknown monoclonal antibody.

WORKFLOW PROTEIN METRICS SOLUTION
Proteomics Byonic
Proteoform profiling Byonic and Intact Mass
Host cell protein analysis Byologic and Byonic
De novo sequencing Supernovo

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Would you like to learn more about our Protein & Peptide Identification?

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Glycosylation is one of the most common and most biologically important posttranslational modifications (PTMs) of proteins, but it is also one of the most difficult to study.  Vaccine research for pathogenic viruses such as herpes, HIV, and hepatitis C, all depend upon an understanding of envelope glycoproteins.  Many cancer biomarkers are either glycoproteins or glycan epitopes on cell surface or secreted glycoproteins.  For other biotherapeutics, glycosylation is one of the critical quality attributes that affect safety and efficacy.

Protein Metrics’ Software Suite has the unique ability to identify and localize N- and O-linked glycans on peptides and to determine and report glycan and glycosylation profiles.

WORKFLOW PROTEIN METRICS SOLUTION
Glycosylation profiling and localization (N- and O-linked) Byologic and Byonic
Intact glycoprotein profiling Intact Mass
Released glycans Byomap

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Would you like to learn more about our Glyco Analysis?

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Analysts who support regulatory filings or product release need robust and compliant tools that can be scaled across many labs.

Protein Metrics’ Byomap™ software supports product verification by quantitative peptide mapping with pivot tables and automated report generation.  Our Intact Mass™ software checks protein identity and glycosylation by intact mass analysis, and Supernovo™ gives detailed end-to-end confirmation of primary sequence.

WORKFLOW PROTEIN METRICS SOLUTION
Product release Byomap, Intact Mass
Quality testing Byomap, Intact Mass
De novo sequencing Supernovo
Modification Localization Byonic

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Would you like to learn more about our Quality/Product Verification?

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Intact mass analysis is a key analytical assay for the identification, characterization, and relative quantification of large molecules. The technique requires minimal sample preparation compared to peptide mapping techniques, and offer clear confirmation and identification of protein species.

Protein Metrics’ Intact Mass™ software is groundbreaking.  It features our Parsimony Algorithm™, the first new algorithm in 25 years for charge state deconvolution. Our Parsimony Algorithm gives many fewer processing artifacts than MaxEnt and can handle the most complicated deconvolution problems, including native MS, non-covalent complexes, and antibody drug conjugates.  Intact Mass also offers batch processing, automated peak assignment, DAR calculation for ADCs, and automated graphical reporting.

WORKFLOW PROTEIN METRICS SOLUTION
Intact mass profiling Intact Mass
Native MS analysis Intact Mass
Antibody Drug Conjugates (ADCs) Intact Mass

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Would you like to learn more about our Intact & Subunit Analysis?

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Bottom-up studies for modification site localization and peptide-level detail are a critical part of the therapeutic protein development and regulatory reporting.  Bottom-up plays a critical role in Drug Discovery for early lead selection, Analytical Development for determining Critical Quality Attributes (CQAs), Process Development for yield and quality optimization, and Biosimilar Development for comparability and regulatory approval.

Protein Metrics’ Software Suite quantifies PTMs and degradants from both single and tandem MS data.  Our software will help you identify and quantify all relevant PTMs and degradants; facilitate consistent, quantitative comparison across samples; automate routine analysis results; and present results to non-mass spectrometry experts in a clear, concise report summary.

WORKFLOW PROTEIN METRICS SOLUTION
PTM Analysis (Oxidation, Deamidation, and other PTMs) Byologic
Peptide Mapping Byologic
Disulfide bond profiling Byologic and Byonic
Sequence variant analysis Byologic and Byonic
Multi-Attribute Method (MAM) Byologic, Byomap, and Byonic
Top-down sequencing Byonic

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Would you like to learn more about our Peptide Level Characterization?

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Mass spectrometry offers a practical alternative to NMR and x-ray crystallography for obtaining structural information from small and impure samples.  Protein Metrics software can be used for oxidative footprinting and other covalent labeling methods, cross-linking, and disulfide-bond analysis.

Protein Metrics’ Software Suite offers unique methods for exploring disulfide bond shuffling and crosslinking via MS/MS analysis and scoring of digests of non-reduced proteins.  In addition, advances within the Byologic module offers a new ability to report on solvent accessibility via chemical labeling and oxidative-footprinting studies.

WORKFLOW PROTEIN METRICS SOLUTION
Solvent Accessibility Byologic and Byonic
Disulfide bond analysis Byologic and Byonic
Epitope mapping Byologic and Byonic
Charge Variant Profiling (CE, or LC) Intact Mass with MS, Byomap with UV

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Would you like to learn more about our Higher Order Structure?

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Some studies require both peptide-level reporting as well as intact mass analysis to guide critical decisions and reporting.

Comparability and biosimilarity studies with Protein Metrics’ Software Suite is straightforward with the use of user-friendly templates and reporting structures that automatically calculate differences between samples without the need for analysts to rely on multiple software packages.

WORKFLOW PROTEIN METRICS SOLUTION
Cell Line Selection Byologic, Byomap, Byonic, and Intact Mass
Stability studies Byologic, Byomap, Byonic, and Intact Mass
Biosimilar studies Byologic, Byomap, Byonic, and Intact Mass
Antibody Drug Conjugates (ADC) Byologic, Byomap, Byonic, and Intact Mass

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Would you like to learn more about our Comprehensive Characterization?

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