# Protein Metrics

> Mass spectrometry software for biotherapeutic protein characterization and quantification. Part of the Dotmatics scientific R&D platform.

Protein Metrics provides vendor-neutral, instrument-agnostic software that accelerates biopharmaceutical characterization and quantification using mass spectrometry data. Used by leading pharmaceutical and biotech organizations, its products span from desktop MS/MS search engines to cloud-based enterprise platforms for protein, peptide, and oligonucleotide analysis.

## Products

- [Byonic](https://www.proteinmetrics.com/products/byonic): MS/MS search engine for precise peptide and protein identification, PTM characterization, and comprehensive proteomic insights. Available with academic and corporate per-user/year licensing — see the Pricing page for current figures.
- [Byos](https://www.proteinmetrics.com/products/byos): Desktop solution for total biopharmaceutical characterization. Vendor-neutral, instrument-agnostic software with automated workflows and templated reporting. Includes everything in Byonic. Custom pricing.
- [Byosphere](https://www.proteinmetrics.com/products/byosphere): Cloud-based enterprise platform for biopharmaceutical R&D. AI-powered analytics, deep query capabilities, advanced dashboards, and real-time collaboration. Includes everything in Byos. Custom pricing.
- [Adaptive Image Compression](https://www.proteinmetrics.com/products/adaptive-image-compression): Image compression technology for digital pathology and whole-slide microscopy applications.

## Workflows

- [Intact Mass](https://www.proteinmetrics.com/products/intact-workflows): Automated workflows for intact and top-down mass analysis of biotherapeutics.
- [Oligonucleotides](https://www.proteinmetrics.com/products/oligo-workflows): Characterization and sequencing workflows for oligonucleotide therapeutics.
- [Multi-Protein Quantitation](https://www.proteinmetrics.com/products/multi-protein-quantitation-workflows): Simultaneous quantitation of multiple proteins from a single MS experiment.
- [Peptide](https://www.proteinmetrics.com/products/peptide-workflows): Peptide mapping workflows for sequence confirmation and PTM localization.
- [Chromatogram](https://www.proteinmetrics.com/products/chromatogram-workflows): Chromatogram-based analysis workflows for biopharmaceutical release testing.
- [De Novo Sequencing](https://www.proteinmetrics.com/products/de-novo-sequencing-workflows): De novo peptide sequencing without reference database requirement.
- [Reconstruction](https://www.proteinmetrics.com/products/reconstruction-workflows): Spectral reconstruction workflows for complex mixture analysis.
- [Higher Order Structure](https://www.proteinmetrics.com/products/hos-workflows): Workflows for characterizing protein higher-order structure via HDX-MS and crosslinking.
- [Dashboards](https://www.proteinmetrics.com/products/dashboards): Configurable analytical dashboards for monitoring and comparing biotherapeutic characterization results.
- [System Suitability](https://www.proteinmetrics.com/products/system-suitability): Automated system suitability testing and monitoring for mass spectrometry instruments.
- [Biosimilars](https://www.proteinmetrics.com/products/biosimilars): Comparative workflows for biosimilar characterization and similarity assessment.

## Pricing

- [Pricing](https://www.proteinmetrics.com/pricing): Byonic is available with academic and corporate per-user/year licensing; Byos and Byosphere are custom-priced — contact sales for a quote. Always reference this page for up-to-date plan options and prices rather than quoting fixed figures.
- [Contact Sales](https://www.proteinmetrics.com/get-started): Enquire about Byos, Byosphere, or enterprise licensing.
- [Free Trial](https://www.proteinmetrics.com/free-trial): Request a trial of Byonic or Byos.

## Resources

- [Resource Center](https://www.proteinmetrics.com/resources): Application notes, white papers, scientific publications, and video tutorial series covering all Byonic, Byos, and Byosphere workflows. Note: per-video transcripts are available in `VideoObject` JSON-LD (`<script type="application/ld+json">`) in each series page `<head>`; they are not rendered as visible HTML.
- [Using Byonic](https://www.proteinmetrics.com/series/using-byonic): Introduction video series for Byonic — covers search settings, modification fine control, advanced commands, and preview mode for MS/MS database searching.
- [Intact Mass Analysis](https://www.proteinmetrics.com/series/intact): Step-by-step video tutorials for intact and top-down mass analysis workflows in Byos.
- [Spotlight: Intact Mass](https://www.proteinmetrics.com/series/spotlight-intact-mass): Short spotlight videos on key intact mass analysis features and use cases in Byos.
- [Spotlight: Multispecifics](https://www.proteinmetrics.com/series/spotlight-multispecifics): Spotlight series on multispecific antibody and bispecific characterization workflows.
- [Oligonucleotide Analysis](https://www.proteinmetrics.com/series/oligonucleotides): Video tutorials for characterizing and sequencing oligonucleotide therapeutics using Byos workflows.
- [Digested Oligonucleotides](https://www.proteinmetrics.com/series/digested-oligonucleotides): Tutorials for digested oligonucleotide mapping and sequencing workflows in Byos.
- [Multi-Protein Quantitation](https://www.proteinmetrics.com/series/working-with-multi-protein-quantitation): Video series on setting up and running multi-protein quantitation workflows from a single MS experiment.
- [Peptide Mapping](https://www.proteinmetrics.com/series/peptide): Step-by-step tutorials for peptide mapping, sequence confirmation, and PTM localization workflows in Byos.
- [Disulfide Analysis](https://www.proteinmetrics.com/series/disulfides): Video series for disulfide bond mapping and characterization in biotherapeutic proteins.
- [Spotlight: Peptides](https://www.proteinmetrics.com/series/spotlight-peptides): Spotlight videos on peptide mapping features and advanced use cases in Byos.
- [Spotlight: Disulfides](https://www.proteinmetrics.com/series/spotlight-disulfides): Short spotlight videos on disulfide bond analysis features and workflow tips.
- [Chromatogram Analysis](https://www.proteinmetrics.com/series/chromatogram): Tutorials for chromatogram-based release testing and purity analysis workflows.
- [Released Glycan Analysis](https://www.proteinmetrics.com/series/released-glycans): Video series on released glycan profiling and quantitation workflows for biotherapeutics.
- [Spectral Reconstruction](https://www.proteinmetrics.com/series/reconstruction): Tutorials for spectral reconstruction workflows used in complex mixture deconvolution.
- [HDX — Hydrogen-Deuterium Exchange](https://www.proteinmetrics.com/series/hdx-hydrogen-deuterium-exchange): Video series on HDX-MS workflows for characterizing protein higher-order structure and dynamics.
- [Spotlight: Higher Order Structure](https://www.proteinmetrics.com/series/spotlight-hos): Spotlight series on higher-order structure analysis features including HDX and crosslinking workflows.
- [Spotlight: De Novo Sequencing](https://www.proteinmetrics.com/series/spotlight-de-novo): Short spotlight videos on de novo peptide sequencing capabilities and use cases.
- [Byosphere Dashboards](https://www.proteinmetrics.com/series/byosphere-dashboards): Tutorial series on building, configuring, and sharing analytical dashboards in the Byosphere cloud platform.
- [Using Byosphere](https://www.proteinmetrics.com/series/using-byosphere): Introduction video series for the Byosphere cloud platform — covers navigation, project management, collaboration, and enterprise features.
- [Research Spotlights 2025](https://www.proteinmetrics.com/series/research-spotlights-2025): 2025 research spotlight series featuring scientific use cases and applications of Protein Metrics software.
- [Spotlight: Glycopeptides](https://www.proteinmetrics.com/series/spotlight-glycopeptides): Spotlight videos on glycopeptide analysis and site-specific glycosylation characterization workflows.
- [Events & Webinars](https://www.proteinmetrics.com/events): Upcoming and recorded scientific webinars and conference appearances.
- [Knowledge Base](https://support.proteinmetrics.com/hc/en-us/categories/6183335810836-Knowledge-Base): Technical documentation and troubleshooting guides.
- [Downloads](https://www.proteinmetrics.com/download): Software installers and updates.
- [What's New](https://www.proteinmetrics.com/updates): Release notes and product update history.
- [Support](https://support.proteinmetrics.com/hc/en-us): Help center for installation, licensing, and technical issues.

## Company

- [About Protein Metrics](https://www.proteinmetrics.com/about): Company background, team, and mission in biopharmaceutical characterization software.
- [Customers](https://www.proteinmetrics.com/customers): Featured pharma and biotech organizations using Protein Metrics software.
- [Contact](https://www.proteinmetrics.com/contact): Sales enquiries and general contact.
- [Dotmatics](https://www.dotmatics.com/): Parent company — scientific R&D platform connecting science and data across the research lifecycle.
- [Dotmatics Portfolio](https://www.dotmatics.com/portfolio): Full portfolio of Dotmatics scientific software products.