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References

RessurectProtein Metrics Collaborators on the cover of ACS Infectious diseases for de novo sequencing of an Antibody! https://lnkd.in/eUUb6-c. Another advance in protection against disease.;

Features

  • Automated de novo sequencing based on robust MS2 scoring algorithms
  • Automated assembly of sequenced peptides onto a mAb framework
  • Convenient project creation via drag-and-drop of MS/MS raw files
  • Enables user-friendly review of results by presenting MS1, M2, and XIC of all peptides in easy-to-use review dashboard.
    Visual comparison of MS1 and MS2 spectra of variant and unmodified forms
  • Summary of the accumulated evidence for each cleavage between amino acid residues – both MS1 (digestion) and MS2 (fragmentation)
  • Rapid rejection of false-positive identifications
  • Label-free quantification of variant relative to the unmodified sequence using XICs
  • Exports figures and tables in variety of formats
Product Description

Supernovo™ is a unique, hands-free solution for end-to-end de novo sequencing of mAbs enabling high throughput protein discovery.

Sequencing monoclonal antibodies (mAbs) is a labor-intensive process. Supernovo™ software automates this analysis and provides a complete antibody sequence, and, just as importantly, metrics and visualizations for validating the sequence.

To learn more and receive a demonstration of the software, please contact info@proteinmetrics.com.

    Automated end-to-end de novo sequencing of mAbs

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