Customer Testimonials

“Protein Metrics’ Byonic™ software is a powerful proteomics tool. Relative to other search engines such as Sequest and Mascot, we have observed a significant gain in speed and overall peptide identifications. Byonic™ is especially powerful in identifying isobarically tagged peptides and peptide PTMs, such as glycosylation. Byonic™ has become the primary tool for peptide identification in our lab, the Stanford University Mass Spectrometry laboratory, and provides our research collaborators with the most robust data sets.”
– Chris Adams, Ph.D., Director of Proteomics, Stanford University Mass Spectrometry, Stanford University
Byonic very quickly became the search engine of choice in my lab as it handles CAD, HCD and ETD data equally well and superior to other search engines we have used. We especially came to rely on the precision with which Byonic identifies PTMs and even unanticipated modifications and sequence variants. Several projects in my lab depend on Byonic’s Wildcard search that allows us to place a large mass window on a specific or all amino acids without decreasing the sensitivity of our search. Using the wildcard modification in combination with Byonic’s integrated top down search became a game changer for our lab. We are now routinely characterizing complex mixtures of 8kDa proteins from organisms with incomplete database in a top down manner without fractionation or sub-digestion. Not only do we identify exact matches to RNA-Seq data, but we identify numerous additional sequence variants and PTMs all top down. The exhaustive annotation of Byonic makes it incredible easy to rapidly validate the identifications. Truly Byonic is the one-stop-shop for exhaustive protein characterization from top to bottom.”
– Beatrix Ueberheide, Ph.D., Assistant Professor, Department of Biochemistry and Molecular Pharmacology, NYU Langone Medical Center

“…[Protein Metrics] is quietly writing the best shotgun proteomics software I have ever seen….”
– Benjamin Orsburn, Ph.D., Senior Application Scientist, Proteomics News Blog

“For us, Byonic has opened new windows in the study of cardiovascular disease.”
– Manuel Mayr M.D., Ph.D., Professor of Cardiovascular Proteomics, King’s College London

“Protein Metrics’ Byonic has changed the way we evaluate our data and even do our up front experiments. The ability of this program to address mass spectra of glycopeptides directly is a Game Changer.  No other program that I am aware of, and we have used many, can compete for assigning glycopeptides. This is not to mention the speed of the searches that are phenomenal….Byonic runs a search faster looking for multiple modifications than the previous program we were using allowing for no modifications!”
-Lance Wells, Ph.D., Prof. Biochem. and Mol. Biol., University of Georgia

“It’s great for our field to have a single search engine, Byonic, which excels at all the different proteomics methods — data-dependent, data-independent, bottom-up, top-down, glycoproteins, and phosphoproteins.”
-Michael MacCoss, Ph.D., Assoc. Professor of Genome Sciences, University of Washington School of Medicine

Byonic has enabled us to evaluate complex tissues and biofluids at the glycopeptide level, allowing simultaneous glycan composition and peptide identification determinations. Using Byonic in our analytical workflow has greatly facilitated evaluation of known key biomarker glycoproteins like PSA, and also improved our ability to discover new cancer biomarker candidates.  Additionally, the Protein Metrics staff have been exceptionally helpful in assisting with any software and data analysis questions that we have had, as well as troubleshooting different experimental approaches.”
-Richard Drake, Ph.D., Professor and Director, Medical University of South Carolina Proteomics Center

Byonic and Preview have become integral tools for our discovery proteomics pipeline.  Searches are rapid, customizable, statistically validated and highly informative.  One of the best aspects is the ability to interface with the vendor and its programmers directly for advice on configurations and for collaborative implementation of new features.”
-Mark Flory, Ph.D., Principal Scientist, Igenica, Inc.

“In my research, we are always looking for unexpected modifications to our proteins.  Protein Metrics’ Byonic software has allowed us to find modifications that we haven’t even considered before.  With other software products we have used we were only able to find what we already knew was there.”
-Joshua S. Sharp, Ph.D., Assistant Research Scientist, University of Georgia

“…[Preview] quickly evaluates your RAW data and gives you an idea of how you should be setting up your searches…this software is very very fast.”
– Benjamin Orsburn, Ph.D., Senior Application Scientist, Proteomics News Blog